NFL Week 1 odds are live following the release of the 2024 NFL schedule on Wednesday.
The season starts with the back-to-back Super Bowl champion Kansas City Chiefs taking on the Baltimore Ravens and continues into the weekend with several high-profile matchups across the league.
NFL Week 1 betting lines mostly favor home teams on the moneyline and spread. Every team believes it is capable of winning the Super Bowl, but only one will be proven correct.
Here’s a comprehensive breakdown of NFL Week 1 odds and every matchup of the opening week.
NFL Week 1 odds
| Matchup | Time (ET) | Moneyline | Spread | Total |
| Ravens at Chiefs | Thursday, 8:20 p.m. | +124/-146 | Chiefs -2.5 | 46.5 |
| Packers vs Eagles* | Friday, 8:15 p.m. | +104/-120 | Eagles -1.5 | 47.5 |
| Steelers at Falcons | Sunday, 1:00 p.m. | +134/-158 | Falcons -3 | 42.5 |
| Cardinals at Bills | Sunday, 1:00 p.m. | +265/-330 | Bills -7 | 48.5 |
| Titans at Bears | Sunday, 1:00 p.m. | +190/-225 | Bears -4.5 | 43.5 |
| Patriots at Bengals | Sunday, 1:00 p.m. | +370/-480 | Bengals -9.5 | 43.5 |
| Texans at Colts | Sunday, 1:00 p.m. | -120/+102 | Texans -1.5 | 48.5 |
| Jaguars at Dolphins | Sunday, 1:00 p.m. | +154/-186 | Dolphins -3.5 | 49.5 |
| Panthers at Saints | Sunday, 1:00 p.m. | +194/-235 | Saints -4.5 | 40.5 |
| Vikings at Giants | Sunday, 1:00 p.m. | -102/-116 | Vikings -1 | 41.5 |
| Raiders at Chargers | Sunday, 4:05 p.m. | +152/-180 | Chargers -3.5 | 42.5 |
| Broncos at Seahawks | Sunday, 4:05 p.m. | +118/-225 | Seahawks -4.5 | 42.5 |
| Cowboys at Browns | Sunday, 4:25 p.m. | -112/-104 | Cowboys -1.5 | 43.5 |
| Commanders at Buccaneers | Sunday, 4:25 p.m. | +166/-198 | Buccaneers -4.5 | 41.5 |
| Rams at Lions | Sunday, 8:20 p.m. | +142/-168 | Lions -3.5 | 51.5 |
| Jets at 49ers | Monday, 8:15 p.m. | +225/-275 | 49ers -6.5 | 45.5 |
Odds provided by FanDuel – accurate as of May 17
NFL Week 1 opening odds
All NFL Week 1 betting lines went live after the NFL schedule release event on Wednesday, May 15. Odds for several games were live before Wednesday after matchup leaked to help drum up excitement for the show.
NFL Week 1 betting lines
Baltimore Ravens (+2.5) @ Kansas City Chiefs (-2.5)
The Chiefs defeated the Ravens in the AFC Championship Game to advance to the Super Bowl last year. Patrick Mahomes and company dominated the league since he became the starting QB but lost on opening night last year, while the Ravens are ready to unleash their new signing, Derrick Henry.
Green Bay Packers (+1.5) vs. Philadelphia Eagles (-1.5)
The Packers were one of the most pleasant surprises of the league last year, while the Eagles lost six of their final seven games after a tremendous start. Philly geared up on both sides while Green Bay continued its steady build around Jordan Love, who was on fire to finish the year.
Pittsburgh Steelers (+3) vs. Atlanta Falcons (-3)
Russell Wilson or Justin Fields? Mike Tomlin seems to prefer the veteran, who will go toe-to-toe with Kirk Cousins in his first game back from an Achilles tear. The Steelers won 10 games a year ago, but the Falcons are one of the top contenders in the NFC.
New England Patriots (+9.5) vs. Cincinnati Bengals (-9.5)
The Patriots have one of the worst assemblies of offensive talent in the league, and they’re banking on their solid defense of a year ago to hit the same level under rookie head coach Jerod Mayo. Meanwhile, the Bengals are hoping for another healthy year from Joe Burrow, who had half of his professional seasons ended prematurely by injuries.
Houston Texans (-1.5) vs. Indianapolis Colts (+1.5)
The Texans are a popular upset pick to win the AFC, but they were one dropped pass in Week 18 away from potentially losing the division to the Colts. Houston spent big on marquee veterans in the summer, while Indy is just happy to have second-year QB Anthony Richardson back under center.
Arizona Cardinals (+7) vs. Buffalo Bills (-7)
The impending debut of Marvin Harrison Jr. is the talk of the town (and the desert). He has the talent to take the league by storm, especially as he prepares to take on the Buffalo Bills’ weakest team during its four-year streak of AFC East championships.
Carolina Panthers (+4.5) vs. New Orleans Saints (-4.5)
The Panthers are only slight underdogs despite winning just two games a year ago and losing Brian Burns over the offseason. Bryce Young’s revenge tour begins against the solid defense but lackluster offense of the Saints.
Jacksonville Jaguars (+3.5) vs. Miami Dolphins (-3.5)
Trevor Lawrence is in a decisive year of his career. He and the Jags were 8-3 before he suffered an ankle injury, which led to them throwing away a commanding division lead and missing the playoffs. Tua Tagovailoa is also entering potentially his final chance to impress the Dolphins, who only beat one team over .500 in 2023.
Minnesota Vikings (-1) vs. New York Giants (+1)
The quarterback battle between either J.J. McCarthy or Sam Darnold and Daniel Jones is not the most exciting of the opening week. The G-Men bolstered their front line, but the visitors played more impressively on both sides a year ago.
Tennessee Titans (+4.5) vs. Chicago Bears (-4.5)
Caleb Williams appears to be one of the best QB prospects ever, and unlike most first-overall picks, he entered an outstanding situation. The Titans had many problems a year ago, including their pass defense, which new coach Brian Callahan will be desperate to fix.
Denver Broncos (+4.5) vs. Seattle Seahawks (-4.5)
Rarely does drafting the sixth quarterback of a given draft work out, but the Broncos did just that with the selection of Bo Nix at 12. They’ll trot into battle against a Seattle team that is in the first year of the post-Pete Carroll era and that hired the architect of the Ravens’ outstanding defense of a year ago, Mike MacDonald.
Las Vegas Raiders (+3.5) vs. Los Angeles Chargers (-3.5)
The Raiders don’t appear to have their long-term answer at quarterback and will start either Aidan O’Connell or Gardner Minshew. The Chargers have their guy in Justin Herbert, but he could be making sacrifices to the running game with coach Jim Harbaugh at the controls.
Washington Commanders (+4.5) vs. Tampa Bay Buccaneers (-4.5)
No college player last year was better than Washington QB and second-overall pick Jayden Daniels. The Commanders underwent more roster turnover than any team in the league and will officially begin their new chapter when they meet the Bucs, who won the NFC South and beat the Eagles in a playoff game a year ago.
Dallas Cowboys (-1.5) vs. Cleveland Browns (+1.5)
Cleveland got Super Bowl-level production from every position on its roster except for quarterback in 2023—unfortunately, that likely won’t change with Deshaun Watson. On the other side, the Cowboys downgraded at several key positions and have put a huge burden on the shoulders of Dak Prescott.
Los Angeles Rams (+3.5) vs. Detroit Lions (-3.5)
The Lions ended the Rams’ season in 2023 during the Wild Card. Matthew Stafford was on fire to finish the year, as was the newly-extended Jared Goff. Neither team was a defensive juggernaut but made investments over the summer to improve their weaknesses.
New York Jets (+6.5) vs. San Francisco 49ers (-6.5)
Can Aaron Rodgers recover from two full seasons of either poor play or time on the couch following his Achilles tear? The Jets had one of the best defenses a year ago, but the same can be said about the Niners, who also appear to have the advantage at nearly every position on offense and at head coach.
NFL Week 1 picks and predictions
Starting with opening night, the Chiefs are in every season for the long haul. They didn’t mind losing to the Lions in Week 1 last year, whereas the Ravens spent the entire spring and summer enraged over their AFC Championship loss and will have a completely new look on offense with Henry. The Ravens at +2.5 picks itself.
Daniel Jones is not the answer in the Big Apple. The arrivals of rookie WR Malik Nabers and edge rusher Brian Burns are great for the future, but Minnesota is more talented with better coaches and equal, if not better QB options. Watch for them to win as an outright underdog.
Another Week 1 spread to consider is the Commanders at +4.5 against the Buccaneers. Daniels is a rookie and will need to adjust, but he was sensational in college and has the talent as a runner to destroy any defense’s game plan. The Bucs also overachieved and are still technically rebuilding.
The Jets are one of the biggest stories of the offseason, but the simple fact is that Aaron Rodgers is years away from his best football, whereas the Niners just made the Super Bowl with a second-year quarterback. It’s tough to believe in the Jets without seeing them put it together on the field, especially with Rodgers’ age and recent injury.
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